T-type Ca2+channel modulation by otilonium bromide
نویسندگان
چکیده
منابع مشابه
T-type Ca channel modulation by otilonium bromide
Peter R. Strege, Lei Sha, Arthur Beyder, Cheryl E. Bernard, Edward Perez-Reyes, Stefano Evangelista, Simon J. Gibbons, Joseph H. Szurszewski, and Gianrico Farrugia Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota; Department of Pharmacology, University of Virginia, Charlottesville, V...
متن کاملT-type Ca(2+) channel modulation by otilonium bromide.
Antispasmodics are used clinically to treat a variety of gastrointestinal disorders by inhibition of smooth muscle contraction. The main pathway for smooth muscle Ca(2+) entry is through L-type channels; however, there is increasing evidence that T-type Ca(2+) channels also play a role in regulating contractility. Otilonium bromide, an antispasmodic, has previously been shown to inhibit L-type ...
متن کاملIrritable Bowel Syndrome: Pathophysiological and Pharmacological Aspects and Use of Otilonium Bromide or Pinaverium Bromide
The Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder worldwide with unclear etiology. It is considered a chronic, multifactorial, relapsing functional bowel disorder normally related to altered motility of gastrointestinal system and the mechanisms involved in its onset and progression are not clear. The abdominal discomfort or pain and modifications in bowel habit ar...
متن کاملmodeling loss data by phase-type distribution
بیمه گران همیشه بابت خسارات بیمه نامه های تحت پوشش خود نگران بوده و روش هایی را جستجو می کنند که بتوانند داده های خسارات گذشته را با هدف اتخاذ یک تصمیم بهینه مدل بندی نمایند. در این پژوهش توزیع های فیزتایپ در مدل بندی داده های خسارات معرفی شده که شامل استنباط آماری مربوطه و استفاده از الگوریتم em در برآورد پارامترهای توزیع است. در پایان امکان استفاده از این توزیع در مدل بندی داده های گروه بندی ...
The Evaluation of Otilonium Bromide Treatment in Asian Patients With Irritable Bowel Syndrome
BACKGROUND/AIMS Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to provide the efficacy of OB in treating Asian IBS patients. METHODS Overall, 117 IBS patients meeting Rome II criteria were enrolled in an 8-week, double-blind, active-controlled and ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2010
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00437.2009